A Synthetic Recursive “+1” Pathway for Carbon Chain Elongation

Nature uses four methods of carbon chain elongation for the production of 2-ketoacids, fatty acids, polyketides, and isoprenoids. Using a combination of quantum mechanical (QM) modeling, protein–substrate modeling, and protein and metabolic engineering, we have engineered the enzymes involved in leu...

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Bibliographic Details
Main Authors: Marcheschi, Ryan J., Li, Han, Zhang, Kechun, Noey, Elizabeth L., Kim, Seonah, Chaubey, Asha, Houk, K. N., Liao, James C.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571861/
https://ncbi.nlm.nih.gov/pubmed/22242720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200313e
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