Close proximity to Igh is a contributing factor to AID mediated translocations

Class switch recombination (CSR) has the potential to generate genomic instability in B cells as activation-induced cytidine deaminase (AID), which mediates this process, is known to target many sites outside Igh. Nonetheless we do not fully understand what factors influence AID targeting genome-wid...

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Main Authors: Rocha, Pedro P., Micsinai, Mariann, Kim, JungHyun Rachel, Hewitt, Susannah L., Souza, Patricia P., Trimarchi, Thomas, Strino, Francesco, Parisi, Fabio, Kluger, Yuval, Skok, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571766/
https://ncbi.nlm.nih.gov/pubmed/22864115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.036
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