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CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection

DNAM-1 gene-deficient (−/−) mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 −/− mice made significantly less cytoplasmic CD8 TNF-α and IL-2 but not IFN-γ than their DNAM-1 +/+ cou...

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Detalhes bibliográficos
Main Authors: Welch, Megan J., Teijaro, John R., Lewicki, Hanna A., Colonna, Marco, Oldstone, Michael B.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571684/
https://ncbi.nlm.nih.gov/pubmed/22579352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.04.006
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