Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans

Cernunnos is a DNA repair factor of the nonhomologous end-joining machinery. Its deficiency in humans causes radiosensitive severe combined immune deficiency (SCID) with microcephaly, characterized in part by a profound lymphopenia. In contrast to the human condition, the immune system of Cernunnos...

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Main Authors: Vera, Gabriella, Rivera-Munoz, Paola, Abramowski, Vincent, Malivert, Laurent, Lim, Annick, Bole-Feysot, Christine, Martin, Christelle, Florkin, Benoit, Latour, Sylvain, Revy, Patrick, de Villartay, Jean-Pierre
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571340/
https://ncbi.nlm.nih.gov/pubmed/23207905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01057-12
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