Scmh1 Has E3 Ubiquitin Ligase Activity for Geminin and Histone H2A and Regulates Geminin Stability Directly or Indirectly via Transcriptional Repression of Hoxa9 and Hoxb4

Polycomb-group (PcG) complex 1 acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. Scmh1 is a substoichiometric component of PcG complex 1 that provides the complex with an interaction domain for geminin. Scmh1 is unstable and regul...

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Auteurs principaux: Yasunaga, Shin'ichiro, Ohtsubo, Motoaki, Ohno, Yoshinori, Saeki, Keita, Kurogi, Toshiaki, Tanaka-Okamoto, Miki, Ishizaki, Hiroyoshi, Shirai, Manabu, Mihara, Keichiro, Brock, Hugh W., Miyoshi, Jun, Takihara, Yoshihiro
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571339/
https://ncbi.nlm.nih.gov/pubmed/23207902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00974-12
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