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Hepatitis C Genotype 1 Mosaic Vaccines Are Immunogenic in Mice and Induce Stronger T-Cell Responses than Natural Strains

Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E...

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Detalhes bibliográficos
Main Authors: Yusim, Karina, Dilan, Rebecca, Borducchi, Erica, Stanley, Kelly, Giorgi, Elena, Fischer, William, Theiler, James, Marcotrigiano, Joseph, Korber, Bette, Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571268/
https://ncbi.nlm.nih.gov/pubmed/23221002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00605-12
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