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Widespread regulation of translation by elongation pausing in heat shock

Global repression of protein synthesis occurs in many stresses and has been attributed primarily to inhibition of translation initiation, although this mechanism may not always explain the full extent of repression. Here, using ribosome footprinting, we show that two hours of severe heat stress trig...

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Main Authors: Shalgi, Reut, Hurt, Jessica A., Krykbaeva, Irina, Taipale, Mikko, Lindquist, Susan, Burge, Christopher B.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570722/
https://ncbi.nlm.nih.gov/pubmed/23290915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.028
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