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Uncovering a region of Hsp90 important for client binding in E. coli and chaperone function in yeast

The Hsp90 family of heat shock proteins is an abundantly expressed and highly conserved family of ATP-dependent molecular chaperones. Hsp90 facilitates remodeling and activation of hundreds of proteins. In this study we developed a screen to identify Hsp90 defective mutants in E. coli. The mutations...

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Hlavní autoři: Genest, Olivier, Reidy, Michael, Street, Timothy O., Hoskins, Joel R., Camberg, Jodi L., Agard, David A., Masison, Daniel C., Wickner, Sue
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570620/
https://ncbi.nlm.nih.gov/pubmed/23260660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.017
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