Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differe...

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Autori principali: Siebold, Christian, Hansen, Bjarke E., Wyer, Jessica R., Harlos, Karl, Esnouf, Robert E., Svejgaard, Arne, Bell, John I., Strominger, Jack L., Jones, E. Yvonne, Fugger, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC357041/
https://ncbi.nlm.nih.gov/pubmed/14769912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308458100
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