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GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

T helper type 2 (Th2) cells secrete IL-4, IL-5, IL-10, and IL-13 and mediate allergic and asthmatic disease. GATA-3 is a Th2-specific transcription factor that appears in overexpression studies and transgenic systems to function as a Th2 lineage determinant. Because GATA-3 is also crucial for develo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pai, Sung-Yun, Truitt, Morgan L., Ho, I-Cheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC357040/
https://ncbi.nlm.nih.gov/pubmed/14769923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308697100
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