Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) constitute a large enzyme family with important biological functions. Inhibition of PTP activity through reversible oxidation of the active-site cysteine residue is emerging as a general, yet poorly characterized, regulatory mechanism. In this study, we describe...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Persson, Camilla, Sjöblom, Tobias, Groen, Arnoud, Kappert, Kai, Engström, Ulla, Hellman, Ulf, Heldin, Carl-Henrik, den Hertog, Jeroen, Östman, Arne
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC357022/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14762163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0304403101
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