Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2′-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells

The DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-CdR) is widely used as an anticancer drug for the treatment of leukemia and solid tumors. Gastric cancer (GC) patients who were positive for caudal type homeobox transcription factor 2 (CDX2) expression showed a higher survival rate compare...

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Main Authors: ZHANG, JIAN-FENG, ZHANG, JIAN-GUO, KUAI, XIAO-LING, ZHANG, HONG, JIANG, WEI, DING, WEI-FENG, LI, ZENG-LI, ZHU, HUI-JUN, MAO, ZHEN-BIAO
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570199/
https://ncbi.nlm.nih.gov/pubmed/23408490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2013.901
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