The Ataxia Telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements

Allelic exclusion is enforced through the ability of antigen receptor chains expressed from one allele to signal feedback inhibition of V-to-(D)J recombination on the other allele. To achieve allelic exclusion by such means, only one allele can initiate V-to-(D)J recombination within the time requir...

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Autores principales: Steinel, Natalie C., Lee, Baeck-Seung, Tubbs, Anthony T., Bednarski, Jeffrey J., Schulte, Emily, Yang-Iott, Katherine S., Schatz, David G., Sleckman, Barry P., Bassing, Craig H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570110/
https://ncbi.nlm.nih.gov/pubmed/23382544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121605
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