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Helios marks strongly autoreactive CD4(+) T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is reported by expression of the transcription factor Helios, which is induced during negative selection but decreases du...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3570102/ https://ncbi.nlm.nih.gov/pubmed/23337809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121458 |
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