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Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins

Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for red blood cell production and exert important cytoprotective effects on select vascular, immune, and cancer cells. To discover novel EPO action modes, we profiled the transcriptome of primary erythroid progenitors. We report...

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Bibliografische gegevens
Hoofdauteurs: Dev, Arvind, Byrne, Susan M., Verma, Rakesh, Ashton-Rickardt, Philip G., Wojchowski, Don M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570101/
https://ncbi.nlm.nih.gov/pubmed/23319700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121762
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