T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

Activation induces extensive changes in the gene expression program of naive CD4(+) T cells, promoting their differentiation into helper T cells that coordinate immune responses. MicroRNAs (miRNAs) play a critical role in this process, and miRNA expression also changes dramatically during T cell dif...

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Bibliographic Details
Main Authors: Bronevetsky, Yelena, Villarino, Alejandro V., Eisley, Christopher J., Barbeau, Rebecca, Barczak, Andrea J., Heinz, Gitta A., Kremmer, Elisabeth, Heissmeyer, Vigo, McManus, Michael T., Erle, David J., Rao, Anjana, Ansel, K. Mark
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570096/
https://ncbi.nlm.nih.gov/pubmed/23382546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111717
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