Expanded RNA-binding activities of mammalian Argonaute 2

Mammalian Argonaute 2 (Ago2) protein associates with microRNAs (miRNAs) or small interfering RNAs (siRNAs) forming RNA-induced silencing complexes (RISCs/miRNPs). In the present work, we characterize the RNA-binding and nucleolytic activity of recombinant mouse Ago2. Our studies show that recombinan...

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Autores principales: Tan, Grace S., Garchow, Barry G., Liu, Xuhang, Yeung, Jennifer, Morris, John P., Cuellar, Trinna L., McManus, Michael T., Kiriakidou, Marianthi
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794174/
https://ncbi.nlm.nih.gov/pubmed/19808937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp812
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