Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy

AIM: The aim of this study was to evaluate the association of genetic variants in the major genes involved in carbamazepine (CBZ) metabolism and transport with its pharmacokinetics in epilepsy patients. MATERIALS & METHODS: Twenty-five SNPs within seven CBZ pathway genes, namely CYP3A4, CYP3A5,...

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Main Authors: Puranik, Yogita Ghodke, Birnbaum, Angela K, Marino, Susan E, Ahmed, Ghada, Cloyd, James C, Remmel, Rory P, Leppik, Ilo E, Lamba, Jatinder K
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570048/
https://ncbi.nlm.nih.gov/pubmed/23252947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.12.180
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