Function of Phe-259 and Thr-314 within the Substrate Binding Pocket of the Juvenile Hormone Esterase of Manduca sexta()

Juvenile hormone (JH) is a key insect developmental hormone that is found at low nanomolar levels in larval insects. The methyl ester of JH is hydrolyzed in many insects by an esterase that shows high specificity for JH. We have previously determined a crystal structure of the JH esterase (JHE) of t...

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Hlavní autoři: Kamita, Shizuo G., Wogulis, Mark D., Law, Christopher S., Morisseau, Christophe, Tanaka, Hiromasa, Huang, Huazhang, Wilson, David K., Hammock, Bruce D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570046/
https://ncbi.nlm.nih.gov/pubmed/20307057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901641x
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