Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas

Drug treatment of malignant gliomas is limited by the intrinsic resistance of glioma stem cells (GSCs) to chemotherapy. GSCs isolated from human glioblastoma multiforme (GBM) expressed metabotropic glutamate receptors (mGlu3 receptors). The DNA-alkylating agent, temozolomide, killed GSCs only if mGl...

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書誌詳細
主要な著者: Ciceroni, C, Bonelli, M, Mastrantoni, E, Niccolini, C, Laurenza, M, Larocca, L M, Pallini, R, Traficante, A, Spinsanti, P, Ricci-Vitiani, L, Arcella, A, De Maria, R, Nicoletti, F, Battaglia, G, Melchiorri, D
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2013
主題:
Original Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569992/
https://ncbi.nlm.nih.gov/pubmed/23175182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.150
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