Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas

Drug treatment of malignant gliomas is limited by the intrinsic resistance of glioma stem cells (GSCs) to chemotherapy. GSCs isolated from human glioblastoma multiforme (GBM) expressed metabotropic glutamate receptors (mGlu3 receptors). The DNA-alkylating agent, temozolomide, killed GSCs only if mGl...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ciceroni, C, Bonelli, M, Mastrantoni, E, Niccolini, C, Laurenza, M, Larocca, L M, Pallini, R, Traficante, A, Spinsanti, P, Ricci-Vitiani, L, Arcella, A, De Maria, R, Nicoletti, F, Battaglia, G, Melchiorri, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569992/
https://ncbi.nlm.nih.gov/pubmed/23175182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.150
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi