Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas

Drug treatment of malignant gliomas is limited by the intrinsic resistance of glioma stem cells (GSCs) to chemotherapy. GSCs isolated from human glioblastoma multiforme (GBM) expressed metabotropic glutamate receptors (mGlu3 receptors). The DNA-alkylating agent, temozolomide, killed GSCs only if mGl...

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Main Authors: Ciceroni, C, Bonelli, M, Mastrantoni, E, Niccolini, C, Laurenza, M, Larocca, L M, Pallini, R, Traficante, A, Spinsanti, P, Ricci-Vitiani, L, Arcella, A, De Maria, R, Nicoletti, F, Battaglia, G, Melchiorri, D
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569992/
https://ncbi.nlm.nih.gov/pubmed/23175182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.150
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