Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas

Drug treatment of malignant gliomas is limited by the intrinsic resistance of glioma stem cells (GSCs) to chemotherapy. GSCs isolated from human glioblastoma multiforme (GBM) expressed metabotropic glutamate receptors (mGlu3 receptors). The DNA-alkylating agent, temozolomide, killed GSCs only if mGl...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ciceroni, C, Bonelli, M, Mastrantoni, E, Niccolini, C, Laurenza, M, Larocca, L M, Pallini, R, Traficante, A, Spinsanti, P, Ricci-Vitiani, L, Arcella, A, De Maria, R, Nicoletti, F, Battaglia, G, Melchiorri, D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569992/
https://ncbi.nlm.nih.gov/pubmed/23175182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.150
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