T-cell death following immune activation is mediated by mitochondria-localized SARM

Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif-containing protein (SARM), the most conserved Toll-like receptors adaptor, is p...

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Bibliografiska uppgifter
Huvudupphovsmän: Panneerselvam, P, Singh, L P, Selvarajan, V, Chng, W J, Ng, S B, Tan, N S, Ho, B, Chen, J, Ding, J L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569988/
https://ncbi.nlm.nih.gov/pubmed/23175186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.144
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