dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently block...

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Udgivet i:Science
Main Authors: Osterloh, Jeannette M., Yang, Jing, Rooney, Timothy M., Fox, A. Nicole, Adalbert, Robert, Powell, Eric H., Sheehan, Amy E., Avery, Michelle A., Hackett, Rachel, Logan, Mary A., MacDonald, Jennifer M., Ziegenfuss, Jennifer S., Milde, Stefan, Hou, Ying-Ju, Nathan, Carl, Ding, Aihao, Brown, Robert H., Conforti, Laura, Coleman, Michael, Tessier-Lavigne, Marc, Züchner, Stephan, Freeman, Marc R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225956/
https://ncbi.nlm.nih.gov/pubmed/22678360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1223899
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