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Proteomics reveals distinct forms of functional crosstalk between proteolysis and phosphorylation during apoptosis

Caspase proteases are principal mediators of apoptosis, where they cleave hundreds of proteins. Phosphorylation also plays an important role in apoptosis, although the extent to which proteolytic and phosphorylation pathways crosstalk during programmed cell death remains poorly understood. Using a q...

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Detalhes bibliográficos
Main Authors: Dix, Melissa M., Simon, Gabriel M., Wang, Chu, Okerberg, Eric, Patricelli, Matthew P., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569040/
https://ncbi.nlm.nih.gov/pubmed/22817901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.040
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