Engineering of Corynebacterium glutamicum for High-Yield l-Valine Production under Oxygen Deprivation Conditions

We previously demonstrated efficient l-valine production by metabolically engineered Corynebacterium glutamicum under oxygen deprivation. To achieve the high productivity, a NADH/NADPH cofactor imbalance during the synthesis of l-valine was overcome by engineering NAD-preferring mutant acetohydroxy...

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Main Authors: Hasegawa, Satoshi, Suda, Masako, Uematsu, Kimio, Natsuma, Yumi, Hiraga, Kazumi, Jojima, Toru, Inui, Masayuki, Yukawa, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Biotechnology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568611/
https://ncbi.nlm.nih.gov/pubmed/23241971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02806-12
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