Identification of Phenylbutyrate-Generated Metabolites in Huntington Disease Patients using Parallel LC/EC-array/MS and Off-line Tandem MS

Oral sodium phenyl butyrate (SPB) is currently under investigation as a histone deacetylation (HDAC) inhibitor in Huntington disease (HD). Ongoing studies indicate that symptoms related to HD genetic abnormalities decrease with SPB therapy. In a recently reported safety and tolerability study of SPB...

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Detalhes bibliográficos
Main Authors: Ebbel, Erika N., Leymarie, Nancy, Schiavo, Susan, Sharma, Swati, Gevorkian, Sona, Hersch, Steven, Matson, Wayne R., Costello, Catherine E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568495/
https://ncbi.nlm.nih.gov/pubmed/20074541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.01.010
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