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High glucose and free fatty acids induce beta cell apoptosis via autocrine effects of ADP acting on the P2Y(13) receptor

While high levels of glucose and saturated fatty acids are known to have detrimental effects on beta cell function and survival, the signalling pathways mediating these effects are not entirely known. In a previous study, we found that ADP regulates beta cell insulin secretion and beta cell apoptosi...

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Autori principali: Tan, Chanyuan, Voss, Ulrikke, Svensson, Siv, Erlinge, David, Olde, Björn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568432/
https://ncbi.nlm.nih.gov/pubmed/22941026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-012-9331-6
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