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The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413

Various radioligands have been used to characterize and quantify the platelet P2Y(12) receptor, which share several weaknesses: (a) they are metabolically unstable and substrates for ectoenzymes, (b) they are agonists, and (c) they do not discriminate between P2Y(1) and P2Y(12). We used the [(3)H]PS...

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Hlavní autoři: Ohlmann, Philippe, Lecchi, Anna, El-Tayeb, Ali, Müller, Christa E., Cattaneo, Marco, Gachet, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568427/
https://ncbi.nlm.nih.gov/pubmed/22892887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-012-9329-0
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