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Role of pertussis toxin-sensitive G-protein, K(+) channels, and voltage-gated Ca(2+) channels in the antinociceptive effect of inosine

Inosine is the first metabolite of adenosine. It exerts an antinociceptive effect by activating the adenosine A(1) and A(2A) receptors. We have previously demonstrated that inosine exhibits antinociceptive properties in acute and chronic mice models of nociception. The aim of this study was to inves...

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Hlavní autoři: Macedo-Junior, Sérgio José, Nascimento, Francisney Pinto, Luiz-Cerutti, Murilo, Santos, Adair Roberto Soares
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568425/
https://ncbi.nlm.nih.gov/pubmed/22806273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-012-9327-2
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