Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration

The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model, designated “miR-183C(GT/GT),” using a gene-trap embryonic stem cell clone. We provide evidence that inactivation of the clu...

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Autori principali: Lumayag, Stephen, Haldin, Caroline E., Corbett, Nicola J., Wahlin, Karl J., Cowan, Colleen, Turturro, Sanja, Larsen, Peter E., Kovacs, Beatrix, Witmer, P. Dane, Valle, David, Zack, Donald J., Nicholson, Daniel A., Xu, Shunbin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568372/
https://ncbi.nlm.nih.gov/pubmed/23341629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212655110
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