Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway

Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of uter...

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Detalhes bibliográficos
Main Authors: Varghese, Binny V., Koohestani, Faezeh, McWilliams, Michelle, Colvin, Arlene, Gunewardena, Sumedha, Kinsey, William H., Nowak, Romana A., Nothnick, Warren B., Chennathukuzhi, Vargheese M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568308/
https://ncbi.nlm.nih.gov/pubmed/23284171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215759110
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