The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation

Human and animal studies suggest that suboptimal early nutrition during critical developmental periods impacts long-term health. For example, maternal overnutrition during pregnancy and lactation in mice programs insulin resistance, obesity, and endothelial dysfunction in the offspring. Here we inve...

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Hlavní autoři: Fernandez-Twinn, Denise S., Blackmore, Heather L., Siggens, Lee, Giussani, Dino A., Cross, Christine M., Foo, Roger, Ozanne, Susan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2012
Témata:
Renal-Cardiac-Vascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568261/
https://ncbi.nlm.nih.gov/pubmed/23070543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1508
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