The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation

Human and animal studies suggest that suboptimal early nutrition during critical developmental periods impacts long-term health. For example, maternal overnutrition during pregnancy and lactation in mice programs insulin resistance, obesity, and endothelial dysfunction in the offspring. Here we inve...

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Bibliographic Details
Main Authors: Fernandez-Twinn, Denise S., Blackmore, Heather L., Siggens, Lee, Giussani, Dino A., Cross, Christine M., Foo, Roger, Ozanne, Susan E.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Renal-Cardiac-Vascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568261/
https://ncbi.nlm.nih.gov/pubmed/23070543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1508
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