Transgenes of the Mouse Immunoglobulin Heavy Chain Locus, Lacking Distal Elements in the 3′ Regulatory Region, Are Impaired for Class Switch Recombination

Podobne zapisy

• Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination.
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• Copy choice mechanism of immunoglobulin heavy-chain switch recombination.
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• The 3′ end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four γ genes
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• Role of PTIP in Class Switch Recombination and Long-Range Chromatin Interactions at the Immunoglobulin Heavy Chain Locus
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