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ENZYMATIC DEGLYCOSYLATION CONVERTS PATHOGENIC NEUROMYELITIS OPTICA ANTI-AQUAPORIN-4 IgG INTO THERAPEUTIC ANTIBODY
OBJECTIVE: Neuromyelitis optica (NMO) is caused by binding of pathogenic autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes, which initiates complement-dependent cytotoxicity (CDC) and inflammation. We recently introduced mutated antibody (aquaporumab) and small-molecule blocker strategies...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567850/ https://ncbi.nlm.nih.gov/pubmed/23055279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23741 |
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