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Decoding the phosphorylation code in Hedgehog signal transduction
Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its deregulation leads to numerous human disorders including cancer. Binding of Hh to Patched (Ptc), a twelve-transmembrane protein, alleviates its inhibition of Smoothened (Smo), a seven-transmemb...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567827/ https://ncbi.nlm.nih.gov/pubmed/23337587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.10 |
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