Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6: IMPLICATIONS IN PARKINSON DISEASE

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic, which induces Parkinson disease. Monoamine oxidase B, present in the mitochondrial outer membrane of glial cells, catalyzes the oxidation of MPTP to...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Bajpai, Prachi, Sangar, Michelle C., Singh, Shilpee, Tang, Weigang, Bansal, Seema, Chowdhury, Goutam, Cheng, Qian, Fang, Ji-Kang, Martin, Martha V., Guengerich, F. Peter, Avadhani, Narayan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567693/
https://ncbi.nlm.nih.gov/pubmed/23258538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402123
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge