Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6: IMPLICATIONS IN PARKINSON DISEASE

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic, which induces Parkinson disease. Monoamine oxidase B, present in the mitochondrial outer membrane of glial cells, catalyzes the oxidation of MPTP to...

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Détails bibliographiques
Auteurs principaux: Bajpai, Prachi, Sangar, Michelle C., Singh, Shilpee, Tang, Weigang, Bansal, Seema, Chowdhury, Goutam, Cheng, Qian, Fang, Ji-Kang, Martin, Martha V., Guengerich, F. Peter, Avadhani, Narayan G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567693/
https://ncbi.nlm.nih.gov/pubmed/23258538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402123
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