Domain Organization of the ATP-sensitive Potassium Channel Complex Examined by Fluorescence Resonance Energy Transfer

K(ATP) channels link cell metabolism to excitability in many cells. They are formed as tetramers of Kir6.2 subunits, each associated with a SUR1 subunit. We used mutant GFP-based FRET to assess domain organization in channel complexes. Full-length Kir6.2 subunits were linked to YFP or cyan fluoresce...

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Autori principali: Wang, Shizhen, Makhina, Elena N., Masia, Ricard, Hyrc, Krzysztof L., Formanack, Mary Lynn, Nichols, Colin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567688/
https://ncbi.nlm.nih.gov/pubmed/23223337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.388629
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