An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer

IL-27 consists of the cytokine subunit p28 and the non-signaling α-receptor EBI3. p28 was shown to additionally act via the non-signaling membrane-bound IL-6 α-receptor (IL-6R) as an agonistic cytokine but also as a gp130 β-receptor antagonist, leading to inhibition of IL-6 signaling. Here, we devel...

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Autores principales: Garbers, Christoph, Spudy, Björn, Aparicio-Siegmund, Samadhi, Waetzig, Georg H., Sommer, Jan, Hölscher, Christoph, Rose-John, Stefan, Grötzinger, Joachim, Lorenzen, Inken, Scheller, Jürgen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567685/
https://ncbi.nlm.nih.gov/pubmed/23209286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432955
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