Complement-mediated Activation of Calcium-independent Phospholipase A(2)γ: ROLE OF PROTEIN KINASES AND PHOSPHORYLATION

In experimental membranous nephropathy, complement C5b-9-induces glomerular epithelial cell (GEC) injury and proteinuria. The effects of C5b-9 are mediated via signaling pathways, including calcium-independent phospholipase A(2)γ (iPLA(2)γ), and mitogen-activated protein kinases (MAPKs) such as extr...

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Bibliografiske detaljer
Main Authors: Elimam, Hanan, Papillon, Joan, Takano, Tomoko, Cybulsky, Andrey V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567641/
https://ncbi.nlm.nih.gov/pubmed/23258543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396614
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