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An evolutionary explanation for the presence of cancer nonstem cells in neoplasms

Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor-propagating cells, while most of the tumor is composed of cells with limited replication poten...

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Autors principals: Sprouffske, Kathleen, Athena Aktipis, C, Radich, Jerald P, Carroll, Martin, Nedelcu, Aurora M, Maley, Carlo C
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567474/
https://ncbi.nlm.nih.gov/pubmed/23397439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12030
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