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Structural insights into the mechanism of four-coordinate cob(II)alamin formation in the active site of the Salmonella enterica ATP:co(I)rrinoid adenosyltransferase (CobA) enzyme: Critical role of residues Phe91 and Trp93
ATP:Co(I)rrinoid adenosyltransferases (ACATs) are enzymes that catalyze the formation of adenosylcobalamin (AdoCbl, coenzyme B(12)) from cobalamin and ATP. There are three families of ACATs, namely CobA, EutT and PduO. In Salmonella enterica, CobA is the housekeeping enzyme that is required for de n...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567240/ https://ncbi.nlm.nih.gov/pubmed/23148601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301378d |
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