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Correlation of Local Effects of DNA Sequence and Position of Beta-Alanine Inserts with Polyamide-DNA Complex Binding Affinities and Kinetics

In order to better understand the effects of β-alanine (β) substitution and the number of heterocycles on DNA binding affinity and selectivity, the interactions of an eight-ring hairpin polyamide (PA) and two β derivatives as well as a six-heterocycle analog have been investigated with their cognate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Shuo, Nanjunda, Rupesh, Aston, Karl, Bashkin, James K., Wilson, W. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567211/
https://ncbi.nlm.nih.gov/pubmed/23167504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301327v
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