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Acquisition of Drug Resistance and Dependence by Prions

We have reported that properties of prion strains may change when propagated in different environments. For example, when swainsonine-sensitive 22L prions were propagated in PK1 cells in the presence of swainsonine, drug-resistant variants emerged. We proposed that prions constitute quasi- populatio...

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Hlavní autoři: Oelschlegel, Anja M., Weissmann, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567182/
https://ncbi.nlm.nih.gov/pubmed/23408888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003158
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