Nebulized Fibrinolytic Agents Improve Pulmonary Fibrinolysis but Not Inflammation in Rat Models of Direct and Indirect Acute Lung Injury

BACKGROUND: Critically ill patients frequently develop acute lung injury (ALI). Disturbed alveolar fibrin turnover, a characteristic feature of ALI, is the result of both activation of coagulation and inhibition of fibrinolysis. Nebulized fibrinolytic agents could exert lung–protective effects, via...

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Autors principals: Hofstra, Jorrit J., Cornet, Alexander D., Declerck, Paul J., Dixon, Barry, Aslami, Hamid, Vlaar, Alexander P. J., Roelofs, Joris J., van der Poll, Tom, Levi, Marcel, Schultz, Marcus J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567078/
https://ncbi.nlm.nih.gov/pubmed/23408962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055262
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