Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux

PURPOSE: Pax3cre-mediated deletion of fibroblast growth factor receptor 2 (Fgfr2) broadly in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral reflux (VUR), although the mechanisms were unclear. Here, we investigated whether Fgfr2 acts specifically in p...

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Main Authors: Walker, Kenneth A., Sims-Lucas, Sunder, Di Giovanni, Valeria E., Schaefer, Caitlin, Sunseri, Whitney M., Novitskaya, Tatiana, de Caestecker, Mark P., Chen, Feng, Bates, Carlton M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567073/
https://ncbi.nlm.nih.gov/pubmed/23409123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056062
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