High level of oxidized nucleosides in thyroid mitochondrial DNA; damaging effects of Fenton reaction substrates

BACKGROUND: The mitochondrial DNA (mtDNA) lies in close proximity to the free radical-producing electron transport chain, thus, it is highly prone to oxidative damage. Oxyphilic type of follicular thyroid carcinoma consists of cells filled – almost exclusively – with aberrant mitochondria. In turn,...

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Huvudupphovsmän: Karbownik-Lewińska, Małgorzata, Stępniak, Jan, Lewiński, Andrzej
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2012
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566933/
https://ncbi.nlm.nih.gov/pubmed/23267669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6614-5-24
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