Lack of correlation between predicted and actual off-target effects of short-interfering RNAs targeting the human papillomavirus type 16 E7 oncogene

BACKGROUND: When designing therapeutic short-interfering RNAs (siRNAs), off-target effects (OTEs) are usually predicted by computational quantification of messenger RNAs (mRNAs) that contain matches to the siRNA seed sequence in their 3′ UTRs. It is assumed that the higher the number of predicted tr...

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Main Authors: Hanning, J E, Saini, H K, Murray, M J, van Dongen, S, Davis, M P A, Barker, E M, Ward, D M, Scarpini, C G, Enright, A J, Pett, M R, Coleman, N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Genetics & Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566827/
https://ncbi.nlm.nih.gov/pubmed/23299538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.564
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